Melissenta skrev 2018-04-07 12:34:49 följande:
hej, nej, ingen katt här..
den enda lösning är desensibilisering, men den är inte säker och ger en massa biverkningar.. tyvärr.
Att sparka på något så komplext som immunförsvaret måste ge bieffekter, för vi begriper det bara inte tillräckligt bra ännu.
Här är ett (sällsynt) exempel på kaskadreaktioner i immunförsvaret under klinisk prövning av ett nytt immunoläkemedel, och hur en man upplevde det:
www.bbc.com/news/magazine-35766627"TGN1412 had a catastrophic effect on the six men's bodies. Headaches and chills rapidly gave way to vomiting, severe pain and shortness of breath.
Swollen tissue, plummeting blood pressure and multiple organ failure followed. One by one, all six were transferred to intensive care.
"I remember quite vividly being pushed through those corridors that hospitals have, and when they go outside and it's like a glass enclosure.
"I remember the cool air hitting me and feeling faint because of the temperature change."
Oldfield ended up in an area where people recover after surgery. Intensive care was short of room.
"There were six of us in this triage space, and that's where they started putting machines on us - haemo-filtration, cleaning your blood."
Despite the drama, it took Oldfield some time to grasp the danger he was in.
He was given steroids, which masked his symptoms, and for a time he thought the adverse reaction to TGN1412 was within expectations - it was a trial after all, and the medical staff treating him were not being explicit about his situation.
"They were just saying we need to put this in the top of your leg, put a big tube into the neck, just to give drugs - it wasn't like 'you are seriously ill'."
At about 02:00, some 18 hours after Oldfield was injected, medical staff called his mother and told her she should come to the hospital.
In the middle of the night, she started driving from her home in Bristol to Northwick Park. "The doctors were saying this is your goodbye perhaps - this person could die," he says.
When his mother arrived, the look in her eyes told him that he was in a bad condition. "I now know that I was very puffy because of the steroids," he says. "The whites of my eyes were orange because of the toxins. I didn't look well."
-- <klipp<
For two weeks, Oldfield's blood was filtered 24 hours a day, he recalls. His immune system had crashed, and his liver, kidneys and lungs were failing. Fluid seeped into his lungs and he had to breathe air through a mask, while a direct line pumped vital drugs into his heart.
Thankfully, like all of the men injected with TGN1412 that day, Oldfield survived. After three weeks in hospital, including seven days in intensive care, he emerged alive.
His short-term memory was impaired - for months afterwards he would forget conversations and appointments - and his immune system made extremely weak. Doctors advised him not to use public transport, and avoid other places where he might be exposed to viruses.
But he was, relatively speaking, fortunate.
At least one of the other men in the test experienced severe swelling of the head, leading to the episode being dubbed the "elephant man" trial.
Another spent four months in hospital, and had his toes and parts of his fingers amputated.
www.bbc.com/news/magazine-35766627